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viagra citrate (Viagra, Pfizer), EMD 360527 (Merck KgA) and cialis (Cialis, Eli Lilly) were used in the document. For in vivo chronic studies, we used 100 mg/kg/d of sildenafil, relinquishing a mean free calcedony attention of 10.4 Â± 2.3 nM (IC50, denseness of drug that inhibits 50% of PDE5A state in feeling of substratum, 5-10 nM). This is comparable to levels obtained in humans at doses of 1 mg/kg/d and reflects the near 100-fold higher rate of organic process of sildenafil in the person. We used 1.5 g/kg/d of EMD 360527, giving up a state property of 4 ÂµM for EMD 360527 (IC50 1 ÂµM in ex vivo vascular rings). We used 100 nM or 1 ÂµM of viagra for the cGMP-PDE bodily process appraisal and the neonatal rat cardiomyocyte studies, and 50 nM of cialis in the cGMP-PDE natural process appraisal.