PDE5A Inhibitors (Soft Tadalafil)

viagra citrate (Viagra, Pfizer), EMD 360527 (Merck KgA) and cialis (Cialis, Eli Lilly) were used in the document. For in vivo chronic studies, we used 100 mg/kg/d of sildenafil, relinquishing a mean free calcedony attention of 10.4 ± 2.3 nM (IC50, denseness of drug that inhibits 50% of PDE5A state in feeling of substratum, 5-10 nM). This is comparable to levels obtained in humans at doses of 1 mg/kg/d and reflects the near 100-fold higher rate of organic process of sildenafil in the person. We used 1.5 g/kg/d of EMD 360527, giving up a state property of 4 µM for EMD 360527 (IC50 1 µM in ex vivo vascular rings). We used 100 nM or 1 µM of viagra for the cGMP-PDE bodily process appraisal and the neonatal rat cardiomyocyte studies, and 50 nM of cialis in the cGMP-PDE natural process appraisal.

16.1.08 07:49

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