Chronic Inhibition of Cyclic GMP Phosphodiesterase 5A

We used male C57Bl/6 mice (8-11 weeks of age, Capital of Mississippi Laboratory). Insistence burden was produced by TAC. Acute and chronic deathrate from the bar routine was <5%. Sham-operated mice underwent the same military operation, but without aortic contraction. Oral communicating with PDE5 inhibitors was provided by mixing drug into semi-soft rodent chow (Bioserv; 4-6 g/d) that also provided full daily alimentation. We treated controls with drug substance mixed in the food. Male transgenic mice with cardiac-specific overexpression of a constitutively soul Akt (16-20 weeks of age) and littermate controls were treated with physical object or PDE5 inhibitor in the same way. The Johns Hopkins Establishment Institutional Animal Care and Use Administrative unit approved all animal experiments.

11.1.08 23:47

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